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The unprecedented message from this respected publication was clear: Nicotine is a drug

Olmedo P, Goessler W, Tanda S, Grau-Perez M, Jarmul S, Aherrera A, Chen R, Hilpert M, Cohen JE, Navas-Acien A, Rule AM (2018) Metal concentrations in e-cigarette liquid and aerosol samples: the contribution of metallic coils

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A separate study was conducted to evaluate the toxic effects of different percentages of expanded shredded tobacco stems (Theophilus et al

So maybe the Japanese firm is onto something